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Presentation and History 60-year-old African American male Diabetic, hypertensive On multiple-dose-per-day antibiotic therapy in hospital Diagnosis Bloodstream infection, confirmed MRSA Treatment Once-daily CUBICIN*
Presentation and History 50-year-old, overweight, white male Diabetic Recurrent foot ulcers History of exposure to another MRSA agent Diagnosis Foot ulcer, presumed MRSA Treatment Once-daily CUBICIN*
Presentation and History 40-year-old, overweight, Hispanic female Medications include a selective serotonin reuptake inhibitor Vein graft Diagnosis Severe cellulitis, presumed MRSA and Streptococcus pyogenes Treatment Once-daily CUBICIN*
Presentation and History 45-year-old white male Renal impairment (with creatinine clearance <30 mL/min) History of poor tolerance to another MRSA agent Diagnosis Catheter-site skin infection,† documented MRSA Treatment Every-other-day CUBICIN*
Presentation and History 35-year-old white male Immunocompromised (due to chronic steroid therapy) Documented allergy to another MSSA agent Diagnosis Wound infection, confirmed MSSA Treatment Once-daily CUBICIN*

These profiles are for educational purposes only and are not based on actual patients. Actual diagnoses and treatments must be determined by attending physicians.

* Please see enclosed prescribing information for dosage and administration.
† Catheter-site infection photo reprinted from Wickham R, Purl S, Welker D. Long-term central venous catheters: issues for care. Semin Oncol Nurs. 1992;8:133, © 1992, with permission from Elsevier.

CUBICIN: The Only Once-Daily Option for MRSA Skin and Bacteremia

Ease of Administration for Outpatient Use

Once-daily, 30-minute, 50-mL infusion
No required monitoring of drug level in blood
Can be given by peripheral line, midline, or peripherally-inserted central catheter
Low potential for drug-drug interaction (not metabolized via CYP450)
Permanent J-code reimbursement: Jo878
24-hour hotline: 1-866-RX-DAPTO

Indications and Important Safety Information

CUBICIN® (daptomycin for injection) is indicated for the following infections:
- Complicated skin and skin structure infections caused by susceptible isolates of the following Gram-positive microorganisms: S. aureus (including methicillin-resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subspecies equisimilis, and Enterococcus faecalis (vancomycin-susceptible isolates only). Combination therapy may be clinically indicated if the documented or presumed pathogens include Gram-negative or anaerobic organisms
- S. aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis, caused by methicillin-susceptible and methicillin-resistant isolates. Combination therapy may be clinically indicated if the documented or presumed pathogens include Gram-negative or anaerobic organisms
The efficacy of CUBICIN in patients with left-sided infective endocarditis due to S. aureus has not been demonstrated. The clinical trial of CUBICIN in patients with S. aureus bloodstream infections included limited data from patients with left-sided infective endocarditis; outcomes in these patients were poor. CUBICIN has not been studied in patients with prosthetic valve endocarditis or meningitis
Patients with persisting or relapsing S. aureus infection or poor clinical response should have repeat blood cultures. If a culture is positive for S. aureus, MIC susceptibility testing of the isolate should be performed using a standardized procedure, as well as diagnostic evaluation to rule out sequestered foci of infection. Appropriate surgical intervention (eg, debridement, removal of prosthetic devices, valve replacement surgery) and/or consideration of a change in antibiotic regimen may be required
CUBICIN is not indicated for the treatment of pneumonia
Clostridium difficile-associated diarrhea (CDAD) has been reported with the use of nearly antibacterial agents, including CUBICIN, and may range in severity from mild diarrhea to fatal colitis. CDAD has been reported to occur over 2 months post-antibiotic treatment. If CDAD is suspected, antibiotic treatment may need to be suspended
Patients receiving CUBICIN should be monitored for the development of muscle pain or weakness, particularly of the distal extremities. In patients who receive CUBICIN, creatine phosphokinase (CPK) levels should be monitored weekly, and more frequently in patients who received recent prior or concomitant therapy with an HMG-CoA reductase inhibitor. In patients with renal insufficiency, both renal function and CPK should be monitored more frequently. Patients who demonstrate unexplained elevations in CPK while receiving CUBICIN should be monitored more frequently
CUBICIN should be discontinued in patients with unexplained signs and symptoms of myopathy in conjunction with CPK elevation >1000 U/L (~5 x ULN), or in patients without reported symptoms who have marked elevations in CPK >2000 U/L (≥10 x ULN)
Most adverse events reported in CUBICIN clinical trials were mild to moderate in intensity. The most common CUBICIN adverse events were anemia, constipation, diarrhea, nausea, vomiting, injection-site reactions, and headache

Please refer to full Prescribing Information

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Copyright ©2008 Cubist Pharmaceuticals, Inc., Lexington, MA, USA.
All rights reserved. CUBICIN is a registered trademark of Cubist Pharmaceuticals, Inc.
All other trademarks or registered trademarks are the property of their respective owners.